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acadamic essay The Academic Essay. The academic essay is merely a specific writing genre#150;as is the love letter, newspaper editorial, or pop-fiction. As a genre, it functions within a set of norms, rules, and conventions. The purpose of this discussion is to make clear to you what those rules and norms are, and how to use them to express your argument clearly. The purpose of the academic essay is to persuade by reasoned discourse. Scholars use the essay amongst themselves to advance ideas. Economics Extended! Its value as an instructional tool is to assist students in human cloning or wrong, developing their critical thinking skills. As you recall, critical thinking is defined as: the ability to read theory accurately, appropriate it meaningfully, apply it independently, generate results based on that application, analyze the results, and form a clear argument based on those results that can be defended with a specific line of reasoning.
A good academic essay engenders this process and clearly demonstrates that the process has been performed successfully. With this in mind let's examine how to write an academic essay. Do you frequently find yourself struggling with the introduction to your essays? Do you not know how to begin the essay? Do you find yourself searching for a generalizing statement that will get things going, and trying to find a delicate balance between BS'ing and economics essay saying something meaningful? If so, that's because you are not following the norms for odyssey, the introduction to the academic essay. Economics Extended Essay! Following this norm actually makes introductions a piece of cake and essay leonard human torpedo gets you right into the body of the essay. Here is the norm: The purpose of the introduction is two-fold: 1. Economics Extended! To introduce the cloning right essay, theoretical framework that will guide your analysis.
2. To introduce the economics essay help, thesis statement that will organize your paper. Following this norm allows you to cut to the chase. No more generalizing statements of philosophical speculation that you venture forth hoping that it won't get shot down. Music! You know, crap like Hemingway was perhaps one of the most visionary authors of extended essay help, his time. or The Western is perhaps the most uniquely American of all the genres. Rather, if the grading rubric for research paper, purpose of the essay is to economics essay help demonstrate that you have appropriated a theory and applied it independently to produce results, then the function of the introduction becomes more focused: to on lockie leonard human torpedo introduce the theory#150;or theoretical framework#150;that you have decided to use. Hence you will find that many essays begin with such statements as In his book. Economics Help! Or, In her essay. IMPORTANT NOTE: One of the main reasons that the norm of the Introduction developed this way is because of an important rule of the Academic Essay: Avoid making statements that you cannot prove. The problem with the generalizing/philosophical/BS'ing statements like Hemingway. and The Western. is that they cannot be proven through reasoned discourse. Moreover, to even try and do so would require voluminous amounts of odyssey, discourse for something that is not even your thesis: what you actually ARE setting out to prove. As a result, the genre of the Academic Essay has evolved into the above norm.
It still meets an introduction's purpose of orienting the reader, it just does so in a very specific manner. Having accomplished that, the expectation for an essay is extended help that you will introduce a thesis statement that is directly related to that theoretical framework (or its application). Argumentative! As a result, a major convention of the academic essay is that: The introduction ends with the thesis statement. Having stated a thesis, you are expected to then go and economics extended essay help prove it through the body of the essay. That said, it is statement important to discuss what's at stake in economics essay, making a thesis statement. There are four basic logical forms for a thesis statement: #149; A banal thesis statement. #149; A simple thesis statement. #149; A complex thesis statement. #149; An impossible thesis statement. Let's discuss each of these quickly before moving on.
A banal thesis statement is a statement that does not really say anything#150;it is in fact meaningless because it is either so overly general or so evident as to not be of significance. Here's an example from literature. A frequent argument students will make is This author used symbolism to make his point. The statement, however, is meaningless precisely because it is not of significance: every author writing literature uses symbolism of one kind or another, either using language metaphorically or metonymically. Human Right Or Wrong Essay! Thus, to attempt to single out or make a distinction of a piece for using symbolism is to not say anything that even needs proving to begin with. A simple thesis statement is not quite what it may sound like. A simple thesis statement means that only one main point or argument is going to be proved. The term simple argument can thus be misleading because the argument itself can and frequently is very theoretically sophisticated.
What makes them simple is economics essay help that in terms of their logical structure, they only take on one line of proof, and argumentative essay hence, their organization of proof will be simple. One has to be careful, however, because sometimes one main argument may require SEVERAL supporting arguments. The example here would be the argument that Star Wars belongs within the Western Genre. Here the writer has only one thing to prove, but in order to extended essay help do so will have to establish the odyssey thesis, elements that comprise the Western Genre and demonstrate how the film embodies them--not a small task. Economics Extended Essay! Simple thesis statements are eminently preferable in terms of writing an essay for a course. It allows you to focus on your points and your proofs rather than getting lost in the organization of your arguments.
A complex thesis statement means that the thesis has more than one point to odyssey thesis prove. Extended Essay! In this respect, the essay will have to organize more than one line of reasoning in so far that more than one thing has to be proven. Complex theses are not necessarily more theoretically sophisticated than simple thesis statements, they are only more difficult to organize clearly. In this respect, they are not worth what they entail and should be avoided. An example of a complex thesis statement would be something like: Faulkner's novels critique the ideologies of patriarchy and racism. Customer Panel Essaytown! This would be an appropriate analysis for the work of Faulkner, but I'm not sure it would be worth it. To begin with, it is not clear what the writer has to gain in economics, terms of proving BOTH of these aspects of the work rather than just the one. Instead, with this complex thesis, there are going to be long sections of the essay leonard human torpedo, essay where half of what needs to be proved will be left suspended while the other half gets discussed. In addition, the thesis picks the work of Faulkner which necessitates discussing every book, rather than just one. Thus it is that an important convention of the academic essay is help that: A complex thesis statement can usually be restructured into a more theoretically sophisticated (if not interesting) simple thesis statement. Thesis Statement! Making an Argument.
As stated earlier, the academic essay is an extended, exercise in reasoned persuasion. In this respect, the thesis statement is an important organizational structure insofar as it establishes how the rest of the essay will be organized. Classical logic maintains that there are 3 basic kinds of persuasive statements: statements of fact, statements of value (or evaluation), and essay statements of policy (or action, which argue what we should do). Unless otherwise specified, the first of economics extended essay help, these, the statement of fact, is the form that the thesis statement for homer, an academic essay should take#150;the obvious exception being when you write evaluative criticism (which you will NEVER do in my course). Statements of fact can themselves be grouped into two basic forms: arguments of classification, and arguments of operation or function. It is possible to make other distinctions, like for example, arguments of relationship (how to things relate to each other) but these distinctions can be readily subsumed into these two basic groups. Arguments of extended, classification are when you establish some sort of criteria, and then argue that something meets or fails to meet that criteria. The earlier example that Star Wars belongs within the Western Genre is an rubric paper for high school, example of an argument of classification. Having established what comprises the Western Genre, the writer will then go on to prove how Star Wars embodies, contains, or possesses those elements. Essay Help! The writer will, in other words, prove that Star Wars meets that criteria. Arguments of operation or function argues in terms of paper school, what something does, or how it functions.
The earlier argument that Faulkner's work critiques the ideology of patriarchy is an example of function. This statement argues that Faulkner's work DOES something: it criticizes the ideology of patriarchy. Note that unlike the argument of classification, the writer of this essay SEEMS to have to do more to prove their thesis. They will not only have to define what the ideology of extended essay help, patriarchy is#150;and thus establish criteria#150;they will also have to cloning or wrong essay demonstrate that Faulkner's work DOES something with that criteria. The question of essay, HOW leads to a discussion of the body of the essay. The Body of the Essay. Grading Rubric For High! From a conceptual standpoint, the function of the body of the essay is to prove the essay, thesis statement laid out in the introduction.
Easy enough. This section discusses how the writer accomplishes that proof. In the discussion of types of argument, I made the point that the writer will have to establish criteria that can be used to prove their argument. The body of the essay is the location where the writer accomplishes that. An introduction is precisely that: It INTRODUCES the theoretical framework and the thesis statement. It does not DESCRIBE or DISCUSS these two things. Argumentative Thesis! This is a fairly common mistake that beginning essay writers make.
They fear that they have not said enough in the intro and as a result, go on to discuss aspects of their theory or elaborate on a thesis. The problem with doing so is that it screws up your organization. What comes next is no longer clear to the reader. If you keep it clear to yourself that the extended essay, purpose of the introduction to your essay is to thesis only INTRODUCE your theoretical framework, and your thesis statement, then the function of the body of your essay will also become evident to the reader. They will expect you to establish criteria so that you can prove your thesis.
As a result, another important norm of the academic essay is: A primary function of the body of the essay is to establish the criteria by which the thesis statement will be proven. Essay Help! Thus it is customer panel essaytown that having argued that Star Wars is a Western, the body of the paper is going to have to first establish the elements that comprise the economics extended help, Western#150;it will have to control essaytown establish the criteria by which the economics extended help, thesis can be proven. To argue that Faulkner's work criticizes thee ideology of patriarchy is going to require that the writer establish what the ideology of patriarchy is. Establishing the criteria by statement on ethics which the economics extended help, thesis statement will be proven leads to the next logical step: demonstrating how the object under investigation meets those criteria. Clearly it is grading for research for high school not enough for the Faulkner essayist to just define what the economics help, ideology of patriarchy is. Their thesis is that Faulkner's work criticizes that ideology. As a result, they will have to point to specific things within the text and argue that they relate to those criteria IN A SPECIFIC WAY#150;in this case through a process of criticism. This process of relating the control essaytown, object of investigation back to help the established criteria is cloning essay another fundamental component of the body of the essay. Without it, the proof is not complete. As silly as that sounds, I kid you not that the most frequent mistake of extended essay, beginning essay writers is a failure to relate their analysis back to the criteria they have established.
Thus it is that another important norm for the academic essay is: Relate the analysis back to the terms and concepts of the established criteria. The Star Wars example brings up another fundamental logical task to this process. From the beginning you have probably thought the Star Wars thesis to statement on ethics not be very feasible. The film is not set in the West, and it occurs in the future. The question becomes, however, whether these are ESSENTIAL criteria to the Western, and if not, what is?
In terms of proving that thesis statement, the writer is going to have to clearly establish what the economics, elements of the Western Genre are, and homer then relate aspects of the film back to ALL of those criteria. Herein lies the essential importance of completeness to that process. Economics! If the Star Wars writer establishes the criteria but can only point to the gun-fighting that occurs in the film, then their essay will fail to persuade. Their essay will fail to persuade precisely because it inadequately addresses the scope of the criteria. Thus it is that another important norm for this process is: Fully address the established criteria. Homer Odyssey! It is extended essay very important to essay on lockie note that fully addressing the scope of the criteria does NOT mean that the object under discussion has to fully meet ALL the criteria. To stick with the economics extended essay, Star Wars example, the writer can not IGNORE the issue of setting and even remotely hope to persuade the audience. Argumentative Essay Music! In some way, the writer is going to help have to address the fact that both time and place are out of the bounds of the Western.
This is the point precisely. The author will have to ADDRESS that point#150;those criteria#150;not necessarily MEET those criteria. In this respect, the writer is going to have make a supporting argument about how these criteria relate to each other in terms of comprising the genre (or in a logical sense the whole). The important point is that all criteria are addressed adequately. Failure to address any of the established criteria creates a gap in logic. Subsequently, the reasoning process (and its ability to persuade) fails. Fully relating the object of the thesis to the established criteria fulfills the logical requirements necessary to persuade reasonably and allows the writer to draw conclusions. Cloning Right Or Wrong! Before that process is discussed, however, it is necessary to examine an extended help, important component of this relating back process. The Role of Description. Relating the object of investigation or the object of the thesis back to the established criteria is necessarily going to involve description.
Description is frequently an unclear and thorny issue for writers of the academic essay#150;especially in thesis statement, terms of scope (how much is enough?). Extended Essay Help! The purpose of description, however, clarifies the human essay, issue of scope. The purpose of description to economics help is to make clear, or establish WHAT in the object of investigation (the film, the scene, the shot) relates to the criteria being used. It therefore becomes important for the writer to on lockie human use description in such a manner as to extended help establish the basis of the relationship between the object and for research paper for high the criteria. Furthermore, the economics, writer should LIMIT description to accomplishing only this task. Added description is not only superfluous, but distracts from trying to prove your argument. As a result, another important norm for the body of the academic essay is: Subordinate description to the purpose of analysis. As stated above the process of fully relating the object of the cloning essay, thesis to the established criteria has the effect of fulfilling the logical requirements. It is THAT task which ultimately persuades, not the conclusion itself.
It is for this reason that, in some respects, the conclusion does not seem to have a FUNDAMENTAL role in essay, the process of reasoned persuasion. That in itself probably accounts for how many dopey tips exist for what to do with a conclusion, like: repeat the thesis statement (like people have forgotten it despite the fact that you've been working to prove it the thesis, entire time) or some other such thing. What to economics essay do with a conclusion if the work of proof is already done? The most effective thing to do with a conclusion is to first signal that the work is coming to close, and then close off the discussion itself by thesis stating something definitive about the work. Like the introduction, then, the conclusion has a dual role: to signal the transition to closure, and to close the discussion with a definitive statement.
The work of the conclusion should reference the thesis, without necessarily repeating the thesis (or the steps by which it was proven) It should then say something definitive that signals closure by pointing to essay help the implications of what you've discussed, by amplifying what you've discussed, or by contextualizing what you've discussed. In each case, you are striving to close discussion by being definitive, and you are taking caution not to violate rule #1 of the academic essay: avoid statements that you cannot prove. Customer Essaytown! To stay with the running examples, the conclusion to economics essay the Faulkner paper could look something like this: . Panel! it therefore serves as an example of how literary texts structure their criticisms of dominant ideologies. (pointing to economics extended help the implications of proving your argument). Thus, far from being a portrait of its time Faulkner's work demonstrates that literary works actively engage ideologies. (amplifying your argument) Rather than a story centered exclusively on war, Hemingway's novel instead participates in the reinforcement of dominant ideologies with American culture. (Contextualizing the argument) Note that the similarity here is how definitive these statements are. They draw upon statement the work that has been done, but say something different and final that is logically based upon what has been discussed. There are, of course, variations on the genre of the academic essay--some rather large difference exist, for example, between the social sciences and extended help the humanites. This discussion is thesis based on the humanties approach. Other variations can result from the economics essay help, idiosyncracies of specific instructors.
To the degree that what is written here sounds heavy handed and inflexible, I caution instead that such tone is trying to reflect the manner in which your own analysis and essaytown writing will need to sound precise and rigorous#150;the standards by which the academic essay is evaluated. The precision and rigor with which these norms and economics conventions are applied should function only to demand that your own analysis and reason engender these standards. They are thus meant to odyssey elevate your thinking, not control it. The principles by which the academic essay structures itself is designed to be a discipline that frees your thinking, not subjugate it. Within its conventions is extended unlimited creative potential whose only demand, ultimately, is that you say something meaningful that others can be persuaded of via your logic. What I have attempted to do here is make the norms and conventions of the genre explicit so that you can refine your skills working within it. Paper For High School! Mastering this genre has the benefit of developing your skill to analyze situations using explicit criteria, and be able to economics make decisions based on that analysis.
More than a few people have found that possession of school, such a skill is invaluable in life and professional endeavors.
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Essay on Rheumatoid Arthritis (RA) | Disease. Read this essay to learn about Rheumatoid Arthritis (RA). After reading this essay you will learn about: 1. Meaning of Rheumatoid Arthritis 2. Distribution and Prevalence 3. Therapy 4. Herbal Remedies. Essay on the Meaning of Rheumatoid Arthritis (RA) Essay on the Distribution and Prevalence of Rheumatoid Arthritis Essay on the Therapy for Rheumatoid Arthritis Essay on the Herbal Remedies for Rheumatoid Arthritis. 1. Meaning of Rheumatoid Arthritis (RA): Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovial joints, ultimately leading to joint destruction and permanent disability.
It is a chronic disease of unknown cause affecting over 2 million adults in the USA and 1% of extended essay, world population. It may be accompanied by the development of other disorders, including anemia, osteoplasia and muscular atrophy, as well as abnormal changes in the skin, eyes, lungs, blood vessels, and statement on ethics heart. Economics Help! RA usually begins with a symmetrical attack on the joints. The inflammatory process in the affected joints causes pain, swelling and deformity. 2. Human Right Or Wrong! Distribution and Prevalence of economics extended help, Rheumatoid Arthritis : RA is leonard torpedo, found in all climatic zones world-wide. Several studies have shown that the extended essay help mean age at grading rubric paper school, which the disease debut is essay help, somewhat above 50 years. It occurs in all racial groups and human cloning right essay affects females 2 to 4 times more frequently than males. Approximately 50% of patients are unable to economics, work within 10 years of onset and the lifetime costs of the disease rival those of coronary heart disease or stroke. Mortality rates among persons with RA are increased at-least 2-fold and correlate with the extent and severity of on lockie torpedo, disease.
There is an extended, increased frequency of RA among first degree relatives and an approximately 30% concordance rate in monozygous twins. A complex association exists between RA and HLA (human leukocyte antigens) genes. Also it is or wrong, observed that particular amino acid sequence in the third variable region of the HLA-D4 molecule may be the element causing susceptibility to RA. RA is essentially an idiopathic disease that is extended, characterized by immune mediated destruction of joints. The etiology of the disease is not well understood, but many factors have been implicated, including altered immune regulation, hormonal influences, infectious triggers and other environmental influences.
Some evidences suggest that the antigens are introduced by control panel an infection, with suspicion falling on the Epistein-Barr virus, Paro viruses and Mycobacteria. A peptidoglycan component of bacterial cell walls has been reported to be arthritogenic in rats and in man (Bennet, 1978). Mostly widely held, although not proved is the view that RA is an autoimmune disease (Maini, 1987). About 80% of patients with RA have a circulating auto-anti-body called rheumatoid factor (RF) against the FC portion of the economics help autologous IgG antibody. Most of the RF is IgM but some is IgG, IgA or IgE. All types of RF form immune complexes with autologous IgG. The IgG-RF immune complexes synthesized within joints and articular spaces activate complement with the resultant accumulation of neutrophils. Odyssey Thesis! Leucocytes are attracted to the immune complexes which, along with the fibrin, form on the surface of the inflamed synovium. These cells, filled with particles of ingested fibrin and immune complex, may be found in the synovial fluid and are called “ RA cells ” or “ rhago-cytes “. In the inflamed synovium, dendritic cells and macrophages (antigen presenting) are scattered among a profusion of lymphocytes.
The proximity of essay help, T cells and antigen presenting cells speaks in favour of a cell mediated immune reaction. Circulating immune complexes are thought to argumentative thesis, underlie the wide ranging extra-articular manifestations of RA. The levels of circulating immune complexes are very high in extended essay help patients with RA. These immune complexes are not cleared rapidly from the system but accumulate in odyssey the joints (Theofilo poulous and Dixon, 1979). This in-turn triggers an essay help, inflammatory response at the joints, causing the erosion and destruction of the synovial membrane and underlying cartilage. The pathogenic events occurring in RA can be defined in four phases: an initiation phase (with no clinical evidence of disease), an early inflammatory phase (which leads to clinical manifestations), a destructive phase (in which, the switch to erosive disease has occurred and RA starts to progress) and a perpetuating phase (in which, the consequences of the human cloning right or wrong disease becomes more severe) (Smolen et al., 1996). The destructive phase of the disease is associated with production of the extended essay chronic granulation tissue or pannus, which spreads over the articular cartilage surface.
Neutral proteolytic enzymes (matrix metallo proteinases) secreted by activated macrophages in the pannus and acidic lysosomal enzymes secreted by polymorphonuclear leucocytes in statement on ethics the synovial fluid, both play a part in bone and extended essay cartilage destruction (Barrett Saklatvala, 1981). The potential mediators of the destruction of the cartilage and essay on lockie leonard subadjacent bone in RA are summarized as follows: Neutrophils in the synovial fluid release reactive free radicals and economics extended help lysosomal enzymes, mitigating the inflammation, while released proteinase and proteoglycanases degrade the cartilage (Mainardi, 1987). Synovial lining cells, activated by inflammation or phagocytosis of immune complexes, elaborate collagenase and large amount of human or wrong, prostaglandin E2 and economics interleukin-1 Lymphocytes (T4 cell) play an important role, the activated T cells produce a variety of lymphokines such as interleukin-2, gamma-interferon, macrophage migration inhibition factor and macrophage activating factor. Activated macrophages elaborate in addition to lytic enzymes and prostaglandins, a variety of monokines, including interleukin-1 and tumour necrosis factor (TNF). Currently interleukin-1 and tumour necrosis factor are accorded a central role, as they are capable of: (a) Stimulating synthesis and release of collagenase by dendritic cells and synovial fibroblasts. (b) Inhibiting the synthesis of proteoglycans by argumentative essay music chondrocytes. (c) Acting as a chemo attractant for neutrophils and lymphocytes.
3. Therapy for Rheumatoid Arthritis: Modern therapeutic approaches with non-steroidal anti-inflammatory drugs (NSAIDs- eg. In-domethaccin, phenyl butazone, and ibuprofen), steroidal (cortisone, and prednisolone), immunosuppressive drugs (methotrexate, azathioprine, cyclophosphamide, and cyclosporine) and disease modifying anti-rheumatic drugs (gold salts, pen-cillamine and sulfasalazine) are used to alleviate the agonizing symptoms due to arthritis. None of the existing above treatments can be considered to be curative or definitive therapies for extended essay help the RA and cloning right or wrong they offer only temporary relief accompanying with various side effects like weight loss, diarrhea, skin rash and alopecia. Although the economics help recent years have brought new information for cloning right or wrong the researchers and clinicians, but the treatment of RA still remains a challenge. Cytokine research has led to idea for the use of anti-cytokine therapy for economics extended help the treatment of RA. Etanercept (recombinant form of the thesis statement p75 TNFR-II) and infliximab (monoclonal antibody directed against TNF-alpha) were the first biological response modifiers approval for the treatment of RA (Lipsky et al., 2000). Both drugs have been designed to bind with TNF-alpha and decrease its bioavailability. Apart from all the above described treatment approaches, scientists are now trying to cure RA using gene therapy, but it is still not fully explored.
Despite early detection, current treatment medications are limited in economics extended essay their efficacy and are frequently toxic. Many patients look for complementary and human cloning right alternative medicine (CAM) options in coping with this debilitating disease. Research has indicated that people suffering from economics essay help pain, as in RA, and those dissatisfied with current treatment are very likely to seek alternative treatment, and an estimated 60- 90% of persons with arthritis use CAM (Cesar Ramos and homer odyssey thesis Ashwini Kumar, 2008). 4. Herbal Remedies for Rheumatoid Arthritis: Medicinal herbs are moving from the fringes to mainstream use with greater number of people seeking remedies and health approaches free from side effects caused by extended essay help synthetic chemicals. Recently, considerable attention has been paid to utilize eco-friendly and bio-friendly plant-based products for the prevention and cure of on lockie human, different human diseases. Economics Essay! Considering the adverse effects of synthetic drugs (Gijtenbeek, 1999; Johnson, 2002), the Western population is looking for natural remedies which are safe and effective. It is documented that 80% of the human world’s population has faith in economics help traditional medicine, particularly plant drugs for their primary healthcare. More than 2000 plants of medicinal value are mentioned in Indian ancient Ayurvedic, Unani and Tibbi systems of medicine. Withania somnifera, popularly known as Ashwagandha is widely considered as the thesis Indian ginseng. Economics Extended! It is a green shrub distributed throughout the drier parts of India, Baluchistan, Pakistan, Afghanistan, Sri Lanka, Congo, South Africa, Egypt, Morocco and rubric for research paper school Jordan.
Various parts of this plant have been used for help centuries to treat variety of ailments (Bhattacharya et al, 2001; Kulkarni et al, 1998). The major biochemical constituents of thesis, Withania somnifera are steroidal alkaloids and lactones, a class of constituents together known as withanolides (Elaskkaetal, 1990). Economics Essay! Withanolides, which are extracted from Withania somnifera, are employed in the treatment of arthritis and are known to be potent inhibitor of angiogenesis, inflammation and oxidative stress. Begum and Sadique (1988), for the first time reported the long term effects of homer thesis, Withania somnifera on adjuvant- induced arthritis in rats. Extended Essay! Studies carried out in panel essaytown our laboratory have demonstrated that oral administration of Withania somnifera root powder reversed the essay help biochemical and immunological changes observed in adjuvant-induced arthritis, an experimental model of RA (Rasool et al, 2007). More recently Ichikawa et al (2006) showed that withanolides can indeed inhibit the activation of transcription factor nuclear factor-KB (NF-KB) and NF- KB-regulated gene expression. Ginger (Zinger officinale Roscoe, Zingiber-acae) is a medicinal plant that has been widely used in Chinese, Ayurvedic and Unani herbal medicines all over the world, since antiquity for arthritis and rheumatism. The anti-inflammatory properties of ginger have been known for centuries. Ginger and human right its constituents like gingerdiones have been reported to have pharmacological properties mimicking dual-acting non-steroidal anti-inflammatory drugs in intact human leukocytes in economics vitro (Flynn et al., 1986). More recently, it has been shown that ginger and its constituents are effective against arthritis through suppression of pro-inflammatory cytokines and chemokine’s produced by synoviocytes, chondrocytes, and leukocytes. Ginger was also found to modulate some biochemical pathways activated in chronic inflammation (Grzanna et al., 2005).
It is essaytown, established that neither ginger nor its constituents produce the gastrointestinal damage that are usually produced by the non-steroidal anti-inflammatory drugs (Konturek et al., 2005). Therefore, ginger appears to be a relatively safe and effective supplement to economics extended essay, reduce symptoms of rheumatoid arthritis. Triphala is the most commonly used Indian ayurveda herbal formulation, comprising the fruits of three trees, Indian goose berry (Emblica officinalis Gaertn, family-Euphobiaceae), Belleric my-robalan (Terminalia belerica Linn. family-Combre-taceae) and Chebulic myrobalan (Terminalia chebula Retzr. Grading Paper School! family-Combretaceae). In Ayurveda, it is an important medicine of the rasayana group and is believed to promote health, immunity and longevity (Sandhyaa et al., 2006). Economics! Recent studies indicate that this triphala might play a role in the prevention and treatment of arthritis through by the inhibition of essay on lockie human, lysosomal enzymes, glycoproteins, lipid peroxidation and inflammatory mediator TNF-alpha in adjuvant-induced arthritic rats (Rasool et al., 2007). Triphala was also found to be effective against monosodium urate crystal-induced inflammation, an experimental model for gouty arthritis (Sabina et al., 2007). Moreover, triphala constituent Emblica officinalis, is essay, already well established against arthritis by reducing it biochemical and rubric for research for high school immunological symptoms (Asmawi et al., 1993). Curcumin is the principal curcuminoid of the popular Indian curry spice turmeric that has commonly used in Chinese and Indian medicine system for centuries. The curcuminoids are polyphenols and essay are responsible for the yellow color of turmeric. Curcumin in several lines of evidence, both in vitro and in vivo, has been well documented as an human torpedo, anti-inflammatory agent. The cyclo-oxy-genase 2 (COX-2) inducible and nitric oxide synthase (iNOS) are important enzymes that mediate inflammatory responses.
Improper up-regulation of COX-2 and iNOS has been associated with pathophysiology of certain types of human cancers as well as inflammatory disorders. Recent studies have demonstrated that eukaryotic transcription factor nuclear factor kB (NF-KB) was involved in regulation of COX-2 and economics extended help iNOS expression. The work from the laboratory of essay music, Aggarwal et al (2006) and others have shown that curcumin can down regulate activation of the transcription of the economics essay expression of the transcription factor NF- Eb, thus leading the down regulation of TNF-alpha, adhesion molecules, matrixmetallo proteinases, COX-2 and other inflammatory intermediates all of which are associated with arthritis. Jackson et al (2006) reported that curcumin inhibited neutrophil activation, synoviocyte proliferation, angiogenesis, and collagenase, thus suggesting that curcumin has therapeutic potential in arthritis. Boswellia serrata (Salai guggul) commonly called as Frankincense is grading for high school, a moderate tree widely distributed in India and the Middle East. Several researches in the past 30 years identified the principal component boswellic acid and its derivatives from the economics gum resin of Boswellia serrata. Boswellic acid has demonstrated the anti-inflammatory as well as anti-arthritic activity against human cloning or wrong serum albumin-induced arthritis and osteoarthritis. Boswellic acid derivative (acetyl-11-keto-beta- boswellic acid) is also reported to contribute anti-arthritic action through the economics essay inhibition of grading rubric for research paper for high school, NF-KB, COX-2 and extended essay help 5-lipo-oxygenase (Jolad et al, 2005). Traditional Chinese Medicines (TCM) have been used for centuries in China to treat various immune-mediated disorders like rheumatoid arthritis. The “ thunder god ” vine, Tripterygium wil- fordii Hook F (TWHf), has been extensively used in China to treat RA.
TWHf not only found to inhibit mitogen-stimulated lymph proliferation, but its active derivatives have also been shown to inhibit production of pro-inflammatory cytokines by monocytes and customer lymphocytes, as well as prostaglandin E2 production via the cyclooxygenase, COX-2, pathway, a potential mechanism of action in patients with RA (Ramgolam et al., 2000). Seventy patients with active symptoms who had not responded to NSAIDs, where found to show improvement (overall effective rate of over 90%) after TWHf treatment within the first four weeks in all parameters like tenderness score, swelling count, morning stiffness and grip strength. Ulmus davidiana Planch (Ulmaceae) (UD) and Clematis mandshurica Rupr (Ranunculaceae) roots have long been known to be anti-inflammatory in traditional Korean medicine. UD demonstrated a strong growth inhibition in tested mouse osteoblasts in vitro, and suppressed proliferating cell nuclear antigen (PCNA) expression, COX-2 expression and PGE2 synthesis in osteoblasts (Seok-Jung Suh et al., 2006). Inhibition of PGE2 synthesis via suppression of COX-2 expression may be responsible for essay help its anti-inflammatory activity.
The ethanolic extract of homer odyssey thesis, Clematis mandshurica at 100mug/ml was found to significantly block the production of the pro-inflammatory mediators, nitric oxide (NO) and prostaglandin E(2) (PGE(2)), in lipopolysaccharide (LPS)/interferon(IFN)-gamma-stimulated mouse peritoneal macrophages, by up to 77% and 59%, respectively. In addition, it significantly inhibited cell proliferation and economics cytokine production (interleukin (IL)-2 and thesis IFN-gamma) in economics splenocytes stimulated with Con A (concanavalin A; 5 mug/ml). RA is a systemic autoimmune disease characterized by chronic inflammation of the on lockie leonard human torpedo synovial joints, ultimately leading to joint destruction and permanent disability. Although the economics extended essay help pathogenesis of RA remains incompletely understood, the treatment for various forms of arthritis like NSAIDs, diseases modifying anti-rheumatic drugs are available in the market, but they suffer from various drawbacks, such as lack of efficacy, excessive side effects and high cost. Nowadays, with increasing awareness on traditional medicines, many patients look for complementary and grading rubric paper school alternative medicine options in coping with this disease, however this growing interest in alternative medical practices requires extensive investigation into their safety and efficacy to prove their usefulness against RA. Before publishing your articles on this site, please read the following pages: